The Crystal Globe Competition, the main competition program of the festival, hosts three Czech world premieres this year: Chica Checa (Czech Republic, Slovakia, France), a new feature film by Šimon Holý, produced by Alžběta Janáčková of Silk Films, Only Beautiful Things to Look At (Slovakia, Czech Republic, Hungary) directed by Ivan Ostrochovský and produced by Punkchart Films (SK) and Pavel Strnad and Petr Oukropec of the Czech company Negativ, and Fruit Gathering (Myanmar, Czech Republic, France), a debut feature by Aung Phyoe, co-produced by Vít Janeček of D1film on the Czech side.

Furthermore, the Proxima section offers Lover, Not a Fighter (Slovakia, Czech Republic), a debut feature by Martina Buchelová, produced by Ninja Films (SK) and Julie Marková Žáčková of NOCHI FILM (CZ), and 33 Steps (Slovakia, Czech Republic) directed by Anna Domček and Šimon Domček and produced by Escadra (SK) and Jiří Konečný of Endorfilm (CZ), both in world premiers.

The Special Screenings program delivers Everything As It Should Be by Bohdan Karásek, produced by Ondřej Lukeš of Beginner's Mind, Gregorius, the Chosen One (Czech Republic, Poland, Romania) directed by Tomasz Mielnik and produced by Mikuláš Novotný of Background Films, A Pint of Ink (Czech Republic, Slovakia) directed by Ester Geislerová and produced by Ondřej Trojan and Aňa Geislerová for Total HelpArt T.H.A., City of Fathers (Czech Republic, Slovakia, Poland) directed by Zdeněk Tyc and produced by Pavel a Eva Váchovi of Bratři, Bára - Diary of a Rockstar, an intimate documentary portrait of Czech rock icon Bára Basiková, directed by Helena Třeštíková and produced by Pavel Strnad and Kateřina Černá of Negativ, Robert Richardson: The White Devil directed by Jana Hojdová produced by Matěj Chlupáček, Jana Hojdová, Nela Schlaichertová and Maja Hamplová for Barletta, A Report for Minerva 2 directed by Miroslav Krobot and Lubomír Smékal and produced by Silvie Michajlova and Ondřej Zima of FILM KOLEKTIV, The Cursed Warrior (Czech Republic, Slovakia) directed by Vojtěch Frič and Tomáš Dianiška and produced by Frame100R, the TV series Filter by David Semler, produced by Czech Television, and lastly Berlinale-premiered If Pigeons Turned to Gold (Czech Republic, Slovakia) by Pepa Lubojacki, produced by Wanda Kaprálová and Klára Mamojková of CLAW films.

Special Screenings – Classics program offers Autumn Spring (2021) by Vladimír Michálek, Igor and After​ (Slovakia, Czech Republic), a portrait of the Slovak cinematographer Igor Luther, directed by Ivan Ostrochovský and produced by Punkchart films (SK), Cinémotif films (CZ), Tainted Horseplay (1988) by Věra Chytilová, and Whisper (1996) by David Ondříček.

Imagina program features world premieres of meditative documentary Because I Have To directed by Jakub Kučera and produced by Tomáš Pertold and Michael Přibil of Perfilm, which centers on the work of the prominent Czech artist Miloš Šejn, and experimental short Volklore by Viktorie Štěpánová, produced by Tomáš Šimon of FAMU.

Horizons program showcases Annecy-premiered animated feature Born in the Jungle (Latvia, Poland, Czech Republic) by Edmuns Jansons, co-produced by Vladimír Lhoták od Hausboat, Cannes-premiered Rehearsals for a Revolution (Czech Republic, Spain) by Pegah Ahangarani, produced by Kaveh Farnam of Prague-based Europe Media Nest and Adrià Monés of Fasten Films (Spain), and lastly Sundance-premiered co-production drama How to Divorce During the War (Lithuania, Luxembourg, Ireland, Czech Republic) by Andrius Blaževičius, co-produced by Bionaut for the Czech side.

This year's Future Frames: Generation NEXT of European Cinema program hosts Orla by Marie Lukáčová.

Lastly, Pragueshorts at KVIFF offers generous selection of notable Czech short films: Better Man by Eliška Jirásková, Dog and Wolf  by Terézia Halamová, Wolfie by Philippe Kastner, and 9 Million Colors by Bára Anna.